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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IRAK1
All Species:
13.94
Human Site:
Y433
Identified Species:
34.07
UniProt:
P51617
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51617
NP_001020413.1
712
76537
Y433
T
H
G
A
R
T
K
Y
L
K
D
L
V
E
E
Chimpanzee
Pan troglodytes
XP_521332
850
89683
Y574
T
H
G
A
R
T
K
Y
L
K
D
L
V
E
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_549367
722
76996
Y434
T
Q
G
A
K
T
K
Y
L
K
D
L
V
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q62406
710
77251
Y433
T
Q
G
A
K
T
K
Y
L
K
D
L
I
E
D
Rat
Rattus norvegicus
Q4QQS0
624
69218
G390
P
E
N
F
I
R
V
G
Q
L
T
K
Q
V
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508862
872
94244
R541
S
A
G
D
G
R
S
R
A
K
Y
L
K
D
L
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_697688
686
76453
Y425
K
H
S
R
D
L
S
Y
G
Q
T
A
E
H
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002312803
404
44281
V170
E
V
K
E
L
L
L
V
Y
E
F
M
Q
K
G
Maize
Zea mays
NP_001132095
412
44547
E178
G
Y
C
A
V
D
S
E
A
S
K
H
R
L
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q06548
410
45501
K176
Y
F
Q
P
L
S
W
K
L
R
L
K
V
A
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
77.1
N.A.
83
N.A.
81
27.6
N.A.
49.4
N.A.
N.A.
36.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
78.9
N.A.
87.8
N.A.
85.2
44.9
N.A.
59
N.A.
N.A.
52.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
N.A.
86.6
N.A.
73.3
0
N.A.
20
N.A.
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
N.A.
93.3
N.A.
93.3
6.6
N.A.
33.3
N.A.
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.8
25.8
N.A.
22.8
N.A.
N.A.
Protein Similarity:
33
36.2
N.A.
35.3
N.A.
N.A.
P-Site Identity:
0
6.6
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
20
13.3
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
50
0
0
0
0
20
0
0
10
0
10
0
% A
% Cys:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
10
10
0
0
0
0
40
0
0
10
20
% D
% Glu:
10
10
0
10
0
0
0
10
0
10
0
0
10
40
30
% E
% Phe:
0
10
0
10
0
0
0
0
0
0
10
0
0
0
0
% F
% Gly:
10
0
50
0
10
0
0
10
10
0
0
0
0
0
10
% G
% His:
0
30
0
0
0
0
0
0
0
0
0
10
0
10
0
% H
% Ile:
0
0
0
0
10
0
0
0
0
0
0
0
10
0
10
% I
% Lys:
10
0
10
0
20
0
40
10
0
50
10
20
10
10
0
% K
% Leu:
0
0
0
0
20
20
10
0
50
10
10
50
0
10
30
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
10
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
20
10
0
0
0
0
0
10
10
0
0
20
0
0
% Q
% Arg:
0
0
0
10
20
20
0
10
0
10
0
0
10
0
0
% R
% Ser:
10
0
10
0
0
10
30
0
0
10
0
0
0
0
0
% S
% Thr:
40
0
0
0
0
40
0
0
0
0
20
0
0
0
0
% T
% Val:
0
10
0
0
10
0
10
10
0
0
0
0
40
10
0
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
10
10
0
0
0
0
0
50
10
0
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _